A Guide to 2C-B-FLY: Ann Shulgin’s Favourite Molecule

Lower doses (5 mg) resemble Adderall or MDMA and don’t produce strong visuals. Additionally, always weigh your dose using a small scale if you’re taking the raw powder. Scales are cheap (less than $20) and could mean the difference between having a positive experience and ending up in a hospital. Reports from people who took part in our survey that used very high doses (40 mg or higher) or mixed 2C-B with other psychedelics like LSD or psilocybin often mention the experience to be “disorientating” (37%). Lower doses of around 5 mg have effects most similar to MDMA or Adderall, while the higher doses (more than 15 mg) offer formidable hallucinogenic effects comparable to LSD, psilocybin, or mescaline.

Cognitive effects

• The hallucinogenic effect of 2C-B-FLY is mediated by its partial agonistic activity at the 5-HT2A serotonin receptor, but also has a high binding affinity for the 5-HT1D, 5-HT1E, 5-HT1A, 5-HT2B and 5-HT2C receptors.
• Snorting 2C-B-Fly is extremely painful, especially if you use the HCl version.The benefit of using this route of administration is that you’d need to take a much lower dose.
• When discovering psychedelics, one quickly discovers LSD and mushrooms, but these molecules can be disorienting and frightening even at fairly low doses.
• The only data we have available comes from anecdotal reports, observational studies, and in vitro research.
• With insufflation, the effects are more abrupt and intense but have a significantly shorter duration, while oral usage results in a milder, longer experience.
• Both compounds share the same phenethylamine base structure but have entirely different functional groups.

Most people suggest the effects of 2C-B are a combination of LSD and MDMA. However, it’s more accurate to suggest the effects of 2C-B resemble mescaline — which is actually the molecule used as inspiration for creating the entire 2C class of drugs, to begin with. The 35 mg dose is a potent psychedelic — and very high doses (50 mg or more) are profoundly psychedelic and have even been known to induce out-of-body experiences. In smaller doses these effects are limited, but higher doses of 2C-B 2c b fly produce intense changes in sensory perception. As part of our ongoing experience surveys, we ask our readers to share their experiences to better understand the effects and common dosages of substances.

• I strive to provide my readers with the most accurate and up-to-date information on microdosing, psychedelic philosophy, and consciousness exploration.
• When we take a substance repeatedly, the body makes changes to adapt to the presence of the substance.
• Another way is to switch up your location and move from one place to another.
• And even with testing, you can’t be 100% sure it’s free from harmful chemicals.
• I’ll admit, I’m not the most educated when it comes to obscure psychedelic research chemicals, so I assumed they were the same thing, but as I continued to do more research, I quickly realized that I was wrong.

This substance is largely metabolized by an enzyme called monoamine oxidase (MAO) 2. It’s the main enzyme responsible for breaking down neurotransmitters, including dopamine, serotonin, and norepinephrine. People taking MAO inhibitor medications (a type of antidepressant) may have a hard time metabolizing 2C-B — which could lead to side effects. One of the main benefits of 2C-B over MDMA is that users usually don’t experience difficulty falling asleep after the experience. 2C-B is often compared to LSD because the visual effects of these two drugs are very similar.

You’ll begin to experience effects about minutes after taking 2C-B-FLY, and the effects usually last between six and twelve hours. You can microdose with 2C-B-Fly but drugs like LSD, psilocybin, and ibogaine are more suited for this. Keep your powder or pills in a cold dark place, preferably with no air.If you don’t do this, 2C-B-Fly will lose potency within a few weeks or months.When you store the substance well, it will last for years or even decades.

Drug Exposé: 2C-B-FLY

However, that’s not to say there aren’t still risks to taking too high of a dose. 2C-B-FLY, like most other powdered substances, can be snorted or boofed (for those who don’t know, that involves taking substances up your butthole) as well. When consuming FLY using these methods, it’s recommended to lower the dose significantly. But it is advised to avoid combinin with other empathogens – (MDMA, 6-APB, MDA, 5-MAPB, 3-MMC), the 2C-B-FLY is suspected to act as an MAOI, and it is thus necessary to avoid any mixture with molecules releasing serotonin. Surprisingly, 2C-B-FLY is very similar to molecules like MDMA or 5-MAPB.

Dose Chart

It has a capacity empathogenic well with him which does not have the same mechanism of action, because weaker than the molecules releasing serotonin. It could be seen as a kind of 2C-B which lasts longer, which offers a clearer and calmer mindset, and which is more focused on physical sensations than on visuals after all. Indeed, at this dosage it is already less compassionate, and as you get higher, it becomes darker and deeper (so to speak?). In fact, it’s as if the 10 and 20 mg range was adapted to those looking for a relatively recreational trip (as it’s quite joyful and pleasant) giving nevertheless a possibility to dive into introspection. 2C-B-FLY includes visual effects with eyes open, which are generally described as wavering, transforming.

2C-B is still considered by many to be the best psychedelic to use during sex of all time. Anecdotal evidence suggests that there are no negative health effects attributed to simply trying it by itself at low to moderate doses or using it very sparingly (although nothing can be completely guaranteed). 2C-B, or 2,5-dimethoxy-4-bromophenethylamine, is a substituted phenethylamine. Substituted phenethylamines are a chemical class of organic compounds that are based upon the phenethylamine structure, a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-B possesses methoxy functional groups CH3O- attached to carbons R2 and R5 as well as a bromine atom attached to carbon R4 of the phenyl ring. Subjective effects include open and closed-eye visuals, time distortion, euphoria, and ego loss.

-B-FLY: Is It The Best Psychedelic For Arousal & Sexual Intimacy?

In the same way that 2C-B-FLY is the dihydro-difuran analog of 2C-B, the 8-iodo equivalent, “2C-I-FLY,” would be the dihydro-difuran analogue of 2C-I, and the 8-methyl equivalent, “2C-D-FLY,” would be the dihydro-difuran analogue of 2C-D. The full name of the chemical is 2-(8-bromo-2,3,6,7-tetrahydrofuro2,3-f 1benzofuran-4-yl)ethanamine. It has been subject of little formal study, but its appearance as a designer drug has led the DEA to release analytical results for 2C-B-FLY and several related compounds. It is strongly recommended that one use harm reduction practices when using this substance. 2C-B is also likely to interact negatively with other stimulating substances, such as amphetamines (Adderall), MDMA, MDA, cocaine, caffeine, and nicotine. Combining these substances could lead to side effects and harm involved with increased heart rate and blood pressure, changes in breathing patterns, jitteriness and muscle tension, dehydration, headaches, blood sugar regulation, and anxiety or panic.

Toxicity and harm potential

Substances that target this specific serotonin receptor have been shown to induce a higher entropic state in the brain by decreasing the activity of a system called the default mode network (DMN). This effect induces more out-of-the-box thinking, alters visual and auditory perception, and enables the activity of otherwise disconnected brain networks to interact with each other. This is a woman that’s personally tried and tested hundreds of psychedelic compounds over several decades. You can also find dihydrodifuranated (FLY) analogs of 2C-C (2C-C-FLY), 2C-I (2C-I-FLY), 2C-D (2C-D-FLY), DOB-FLY (bromo-dragonFLY), TFM-FLY, and many others. However, none of these other FLY compounds are as popular in the research chemical space as 2C-B-FLY. Here, we’ll explore what has some psychonauts declaring 2C-B-FLY is the “best psychedelic for sexual intimacy.” We’ll cover dosage, safety, and a bit about this unique psychedelic compound’s history.

It’s also dangerous to combine FLY with any type of MAOi-containing substance, such as ayahuasca or SSRIs. All this to say that it’s probably best to consume FLY on its own. 2C-B-FLY, much like its more well-known cousin 2C-B, is typically taken orally. Moderate doses range between 10 mg – 18 mg, with the effective dose starting as low as 2 mg. Strong doses are anywhere between 18 mg – 25 mg, and heavy doses are anywhere above 25 mg.

-B vs. Mescaline

Surprisingly LSD will give the visuals a touch of precision, as if the world was cut with a razor, everything is precise, sharp, the mindset also goes much further. This mixture allows to reach the deep and a bit chaotic psychedelism of the acid, while remaining quite stable with the 2C-B-FLY which gives us this empathy to dive quietly. Otherwise I always mixed the cannabis with 2C-B-FLY I was just waiting for the first 3-4 hours of the high and the beginning of the plateau to pass, that I felt I had some stability with going further.